<rdf:RDF
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    xmlns:ns1="http://metadb.riken.jp/db/rikenbrc_mouse/"
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    xmlns:ns11="http://purl.org/net/cito/"
    xmlns:ns6="http://metadb.riken.jp/db/bioresource_schema/"
    xmlns:ns4="http://metadb.riken.jp/terms/xsearch#"
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:ns9="http://purl.obolibrary.org/obo/"
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    <ns7:SIO_001279 rdf:parseType="Resource">
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    <ns7:SIO_001279 rdf:parseType="Resource">
    </ns7:SIO_001279>
    <ns1:strainDevelopment xml:lang="en">Developed by Takashi Sonoki, Department of Hematology and Oncology, Wakayama Medical University in 2009.  The transgene was injected into the pronuclei of C57BL/6J fertilized eggs.  The transgene was integrated into the chromosome 15 in the line 116, chromosome 6 in the line 005-I (005-1), and chromosome 5 in the line 005-II (005-2), respectively.  Line 116 (RBRC04867), Line 005-I (RBRC04868), Line 005-II (RBRC04869).</ns1:strainDevelopment>
    <ns1:donorDNA>human immunoglobulin heavy chain endogenous enhancer (Emu), mouse immunoglobulin heavy chain VH promoter, Rat beta-globin genomic DNA, mouse Pre-miR125-b-1 genomic DNA</ns1:donorDNA>
    <ns7:SIO_001279 rdf:parseType="Resource">
    </ns7:SIO_001279>
    <ns5:organism rdf:parseType="Resource">
    </ns5:organism>
    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainType_24"/>
    <ns4:termsAndConditions xml:lang="ja">条件を付加する。利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Leukemia. 2011 Dec;25(12):1849-56. doi: &lt;br&gt;研究成果の公表にあたって謝辞の表明を必要とする。&lt;br&gt;学術機関の学術研究に限る。営利機関の利用希望者は、事前に利用条件等につき寄託者と合意し、提供承諾を得ること。利用者が本件リソースを使用して得られた研究成果に基づき特許等の申請、及び事業活動を行う場合は、寄託者と別途協議を行う。</ns4:termsAndConditions>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_8"/>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_6"/>
    <ns4:application>Immunology and Inflammation Research</ns4:application>
    <rdfs:label xml:lang="en">C57BL/6-Tg(IGHEmu/VH-preMir125b-1)005-1Wakh</rdfs:label>
    <rdfs:label>C57BL/6-Tg(IGHEmu/VH-preMir125b-1)005-1Wakh</rdfs:label>
    <ns6:brs_depositor xml:lang="en">Takashi SONOKI</ns6:brs_depositor>
    <ns4:termsAndConditions xml:lang="en">Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Leukemia. 2011 Dec;25(12):1849-56. doi: In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.  For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.  RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from use of the BIOLOGICAL RESOURCE.</ns4:termsAndConditions>
    <ns1:strainDevelopment xml:lang="ja">和歌山県立医科大学・園木孝志先生（2009）。C57BL/6背景。ライン116（RBRC04867）、ライン005-I（RBRC04868）、ライン005-II（RBRC04869）</ns1:strainDevelopment>
    <dcterms:identifier>RBRC04868</dcterms:identifier>
    <ns11:citesAsAuthority rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/21738213"/>
    <ns6:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_3"/>
    <ns6:brs_depositor xml:lang="ja">園木　孝志</ns6:brs_depositor>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns1:references rdf:parseType="Resource">
    </ns1:references>
    <dcterms:references rdf:resource="http://identifiers.org/pubmed/21738213"/>
    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Approval form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns4:addinfo>
    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_4"/>
    <ns6:brs_depositedBy rdf:parseType="Resource">
    </ns6:brs_depositedBy>
    <ns6:brs_hasAllele rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/brc_allele1029"/>
    <ns6:brs_geneticBackground rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/geneticBackground_5"/>
    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/straintype_2"/>
    <ns9:RO_0002162 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
    <dc:description xml:lang="en">These transgenic mice express a mouse microRNA129b-1 (precursor) under the control of the Human IGHEmu enhancer/mouse VH promoter.  Tg mice exhibit IgM negative B-cell neoplasms, and die within 15-30 weeks of age in the line 116, 30-60 weeks of age in the line 005-I (005-1), and 30-45 weeks of age in the line 005-II (005-2), respectively.</dc:description>
    <ns1:colonyMaintenance xml:lang="ja">Carrier x Noncarrier [C57BL/6JJcl]</ns1:colonyMaintenance>
    <ns1:colonyMaintenance xml:lang="en">Carrier x Noncarrier [C57BL/6JJcl]</ns1:colonyMaintenance>
    <ns7:SIO_001279 rdf:parseType="Resource">
    </ns7:SIO_001279>
    <ns6:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_2"/>
    <rdfs:seeAlso rdf:resource="http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC04868"/>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <skos:altLabel xml:lang="en">B6-Emu-miRNA125 Tg#005-1</skos:altLabel>
    <skos:altLabel xml:lang="ja">B6-Emu-miRNA125 Tg#005-1</skos:altLabel>
    <rdfs:subClassOf rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/Strain"/>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns1:isRecombinant rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean"
    >true</ns1:isRecombinant>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <dc:description xml:lang="ja">マウスmiRNA125b-1を含むDNA断片を免疫グロブリン重鎖エンハンサーとプロモーターの下流につなげたトランスジェニックマウス。。生後15～30週齢 (ライン116) 、生後30-60週齢 (ライン005-I) 、および生後30-45週齢 (ライン005-II) でIgM陰性B細胞性腫瘍を発症して死亡する。トランスジーン挿入部位は15番染色体 (ライン116) 、6番染色体 (ライン005-I) 、および5番染色体 (ライン005-II) 。リンパ球の減少、脾臓肥大が頻発、時にリンパ節肥大がある。</dc:description>
    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
    <ns4:resourceTypeLink rdf:resource="http://metadb.riken.jp/terms/xsearch#resource_type_transgene"/>
    <ns7:SIO_001279 rdf:parseType="Resource">
    </ns7:SIO_001279>
  </rdfs:Class>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/RecoveryTestResult_1283">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC04868"/>
  </rdf:Description>
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